Suicide transport: destruction of neurons by retrograde transport of ricin, abrin, and modeccin |
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Authors: | R G Wiley W W Blessing D J Reis |
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Abstract: | Certain toxic lectins, including ricin, are retrogradely transported along neuronal processes to the cell body where they inactivate ribosomes, resulting in neuronal death. This process of "suicide transport" suggests a powerful new experimental strategy for solving neurobiological problems. |
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