The expression of sialyl Lewis X in canine and feline mammary gland tumors |
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Authors: | Nakagawa Takayuki Uyama Rina Ohashi Emi Takahashi Tomoko Hong Sung Hyeol Mochizuki Manabu Matsunaga Satoru Nishimura Ryouhei Sasaki Nobuo |
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Affiliation: | Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan. |
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Abstract: | The expression of sialyl Lewis X (sLe(x)) in 93 canine and 15 feline mammary gland tumors (MGT) obtained by surgical resection at Veterinary Medical Center, the University of Tokyo was examined by immunohistochemistry. Their clinicopathological features and prognosis were also reviewed. Approximately 60% of MGT tissues showed sLe(x) positive expressions, while all normal mammary gland tissues were negative. However, its expression was not correlated with clinicopathological features and prognosis significantly. This study suggests that sLe(x) may be a tumor-associated antigen in canine and feline MGTs. |
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