植物miR159靶向MYB基因家族的调控作用及其跨界调控哺乳动物生理功能的研究进展

植物miR159靶向MYB基因家族在植物的生长发育、新陈代谢、逆境响应及病原防御等多种生理过程中发挥关键作用。植物miR159可以跨界调控哺乳动物的生理功能,如抑制肿瘤生长、改善能量代谢、抗氧化应激、调节机体免疫功能等。阐述了miR159通过调控MYB基因家族参与多种植物营养生长、逆境胁迫、开花和果实发育过程,以及外源性植物miR159跨界调控哺乳动物生理功能和对乳腺癌的调控作用,以期为后续深入研究植物miR159的调控网络以及跨物种调控机制提供参考。

Advances in Regulative Role of Plant miR159 Targeting MYB Gene Family and Its Cross-kingdom Regulation in Mammalian Physiological Functions

Plant miR159 has been found to play a key role in a variety of physiological processes such as growth and development, metabolism, response to stress, and pathogen defense in plant by targeting MYB gene family. It has also been proved to have a cross-kingdom regulative role in mammalian physiological functions, such as inhibition of tumor growth, improvement of energy metabolism, anti-oxidative stress and regulation of immunity. This paper described the involvement of miR159 in regulation of nutritional growth, response to stress, flowering and fruit development in a variety of plants, and reviewed the cross-kingdom regulative role of exogenous plant miR159 in mammalian physiological functions and breast cancer, in hoping to provide references for the subsequent study on the regulative network and cross-kingdom regulative mechanism of plant miR159.