产丁酸菌的产酸机制及其在调控肠道健康中的作用研究进展

复杂和多样化的肠道微生物群落对宿主健康发挥着重要作用。产丁酸菌代表了宿主肠道微生态一个重要的功能性群体，多数为革兰阳性厌氧菌。人们发现，该类菌和微生物失调引发的消化道炎症等现象息息相关，因此产丁酸菌成为行业研究热点。产丁酸菌能够利用食物(饲料)中不易消化的碳水化合物合成丁酸，通过调控肠道菌群结构、为肠道上皮细胞供能、增强肠黏膜屏障功能等维护肠道健康，发挥对宿主健康的有益作用。本文从产丁酸菌的生物学分类、消化道产酸机制、肠道炎症调控作用及应用进展等方面做了系统综述，旨在阐明产丁酸菌与宿主健康的互作机制，并提出产丁酸菌的未来发展方向。

Research Progress of Acidogenic Mechanism of Butyrate-Producing Bacteria and Its Regulation on Intestinal Health

Complex and diverse intestinal microbial communities play an important role in the host health. Butyrate-producing bacteria represent an important functional group in host intestinal microecology, and most of them are Gram-positive anaerobic bacteria. It is found that butyrate-producing bacteria are closely related to the gastrointestinal inflammation caused by microbial imbalance, so butyrate-producing bacteria became an industry research hotspot. Many studies have shown that butyrate-producing bacteria can confer a health benefit on the host by producing butyrate with indigestible carbohydrates to maintain intestinal bacterial balance, supply energy for intestinal epithelial cells and enhances the function of intestinal mucosal barrier. The biological classification distribution of butyrate-producing bacteria, the mechanism of digestive tract acid production, the regulation of intestinal inflammation and its application progress are systematically reviewed in this paper, in order to elucidate the mechanism of the interaction between butyrate-producing bacteria and host health, and future directions for butyrate producing bacteria are suggested as well.