Sepsis-Induced Acute Kidney Injury in Equine: Current Knowledge and Future Perspectives |
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| Affiliation: | 1. Animal Research Facility, Urology and Nephrology Centre, Faculty of Medicine, Mansoura University, Mansoura, Egypt;2. Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt;3. Department of Nephrology, Urology and Nephrology Centre, Faculty of Medicine, Mansoura University, Mansoura, Egypt;1. University Clinic for Horses, Department for Small Animals and Horses, University of Veterinary Medicine Vienna, Wien, Austria;2. University Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Wien, Austria;3. Royal (Dick) School of Veterinary Studies, University of Edinburgh, Scotland, UK;1. Department of Clinical Studies, College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Ahsa, Saudi Arabia;2. Departments of Veterinary Medicine, Infectious Diseases, and Fish Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt;3. Department of Physiology, Biochemistry and Pharmacology (Biochemistry), College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Ahsa, Saudi Arabia;4. Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt;1. Department of Cardiology, Istanbul University Cardiology Institute, Istanbul, Turkey;2. Department of Biochemistry, Istanbul University Cardiology Institute, Istanbul, Turkey |
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| Abstract: | Sepsis in equine describes a broad range of disorders with different underlying causes and often different prognoses. The syndrome can rapidly progress to septic shock and can result in hypoperfusion with subsequent multiple organ dysfunction including acute kidney injury (AKI). Despite extensive research and progress have been performed in several fields in equine medicine, the incidence as well as the mortality rate of sepsis-induced AKI remains unclear. Although sepsis is considered as the leading cause of AKI, the underlying pathophysiologic mechanisms are not completely understood and still a subject of ongoing debate. The aim of this article is to provide a comprehensive review of the pathophysiology of sepsis-induced AKI, and to outline the diagnostic as well as the therapeutic potentials of the disease. |
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| Keywords: | Sepsis AKI Equine Pathophysiology Diagnosis Therapeutic potentials |
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