| 牛病毒性腹泻病活疫苗BVDV2/JZ05-1株毒力返强试验 |
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| 引用本文： | 李海涛,苗利光,刘艳环,王松,王文昊,安亚雄,冯卓. 牛病毒性腹泻病活疫苗BVDV2/JZ05-1株毒力返强试验[J]. 特产研究, 2012, 34(1): 6-7,26 |
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| 作者姓名： | 李海涛 苗利光 刘艳环 王松 王文昊 安亚雄 冯卓 |
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| 作者单位： | 中国农业科学院特产研究所,吉林吉林,132109 |
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| 基金项目： | 吉林省科技发展计划项目(20100219) |
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| 摘 要： | 研究了BVDV2/JZ05-1株免疫犊牛后是否会出现毒力返强现象.以病毒含量为10-7.26 TCID50/mL的BVDV2/JZ05-1活疫苗滴鼻免疫犊牛(4mL/头),通过疫苗回滴,连续临床观察,采集抗凝血和鼻拭子,对淋巴细胞数量变化进行分析,并从淋巴细胞和鼻拭子中分离病毒.结果表明,BVDV活疫苗BVDV2/JZ05-1株免疫犊牛没有出现BVDV感染的临床症状,淋巴细胞数量正常,鼻拭子和淋巴细胞病毒分离阴性.可见,该毒株对犊牛免疫没有出现毒力返强的现象.
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| 关 键 词： | 牛病毒性腹泻 病毒 毒力返强 |
Study on Pathogenicity of Live BVDV2/JZ05-1 Vaccine |
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| LI Hai-tao , MIAO Li-guang , LIU Yan-huan , WANG Song , WANG Wen-hao , AN Ya-xiong , FENG Zhuo. Study on Pathogenicity of Live BVDV2/JZ05-1 Vaccine[J]. Special Wild Economic Animal and Plant Research, 2012, 34(1): 6-7,26 |
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| Authors: | LI Hai-tao MIAO Li-guang LIU Yan-huan WANG Song WANG Wen-hao AN Ya-xiong FENG Zhuo |
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| Affiliation: | (Institute of Special Wild Economic Animals and Plants,CAAS,Jilin 132109,China) |
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| Abstract: | The aim of this experiment was to study the pathogenicity on calves after intranasal immunization with BVDV2/JZ05-1(The levels of virus was 10-7.26 TCID50/mL).The clinical symptoms were observed continuously,while the anticoagulation from vein and the nasal swabs were collected.The number of lymphocytes from the calves was analyzed.The existence of virus in the nasal swabs and the lymphocytes was also studied.The result showed that symptoms of BVDV were not observed in calves,the number of lymphocytes in calves was normal,and the virus had not been got from the nasal swabs and the lymphocytes.Therefore,there was no pathogenicity on calves after immunization with BVDV2/JZ05-1. |
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| Keywords: | Bovine viral diarrhea Virus Pathogenicity |
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