| 五味子软胶囊中防腐剂对羟基苯甲酸乙酯的测定 |
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| 引用本文： | 王诗惠,张薇,张金萍,毛丽超,李金卓,金向群. 五味子软胶囊中防腐剂对羟基苯甲酸乙酯的测定[J]. 特产研究, 2012, 34(1): 60-62 |
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| 作者姓名： | 王诗惠 张薇 张金萍 毛丽超 李金卓 金向群 |
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| 作者单位： | 吉林大学药学院,长春,130021 |
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| 基金项目： | 吉林省科技发展计划项目(YYZX201132-1) |
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| 摘 要： | 建立用高效液相色谱法测定五味子软胶囊中防腐剂对羟基苯甲酸乙酯的方法.色谱柱Diamonsil C18 (4.6mm×250mm,5μm),流动相甲醇-乙酸铵(0.02mol/L)( 70:30),流速1mL/min,检测波长258nm,柱温25℃.五味子软胶囊中对羟基苯甲酸乙酯的线性范围0.01～0.05μg/μL,平均回收率95.2％,RSD 1.91％.本测定方法简单,专属性强,结果准确可靠,重现性较好.
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| 关 键 词： | 高效液相色谱法 对羟基苯甲酸乙酯 含量测定 |
The Determination of Preservative Ethylparaben in Schisandra Chinensis Soft Capsule |
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| WANG Shi-hui , ZHANG Wei , ZHANG Jin-ping , MAO Li-chao , LI Jin-zhuo , JIN Xiang-qun. The Determination of Preservative Ethylparaben in Schisandra Chinensis Soft Capsule[J]. Special Wild Economic Animal and Plant Research, 2012, 34(1): 60-62 |
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| Authors: | WANG Shi-hui ZHANG Wei ZHANG Jin-ping MAO Li-chao LI Jin-zhuo JIN Xiang-qun |
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| Affiliation: | (School of Pharmaceutical Sciences of Jilin University,ChangChun 130021,China) |
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| Abstract: | To establish a HPLC method for determination of ethylparaben in schisandra chinensis soft capsule,the detection condition as follows: a Diamonsil C18 column(5μm,200×4.6mm) with Methanol-ammonium acetate(0.02mol/L)(70:30) as mobile phase;the detection wavelength was 258nm;the column temperature was 25℃.The calibration curve was linear in the range of 0.01～0.05μg/μL(r=0.999 6) for ethylparaben.The average recovery of ethylparaben was 95.2% with RSD= 1.91%(n=5).The HPLC method is convenient and accurate.It also had good reproducibility. |
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| Keywords: | HPLC Ethylparaben Determination of content |
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