Furobenzotropolones A,B and 3-Hydroxyepicoccone B with Antioxidative Activity from Mangrove Endophytic Fungus Epicoccum nigrum MLY-3 |
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| Authors: | Ge Zou Qi Tan Yan Chen Wencong Yang Zhenming Zang Hongming Jiang Shenyu Chen Bo Wang Zhigang She |
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| Affiliation: | 1.School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China; (G.Z.); (Q.T.); (Y.C.); (W.Y.); (Z.Z.); (H.J.); (S.C.);2.National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China |
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| Abstract: | Three new metabolites, furobenzotropolones A, B (1–2) with unusual benzene and dihydrofuran moieties and 3-hydroxyepicoccone B (3), together with seven known compounds (4–10) were obtained from the endophytic fungus Epicoccum nigrum MLY-3 isolated from the fresh leaf of mangrove plant Bruguiear gymnorrhiza collected from Zhuhai. Their structures were assigned by the analysis of UV, IR, NMR, and mass spectroscopic data. Compound 1 was further confirmed by single-crystal X-ray diffraction experiment using Cu Kα radiation. In antioxidant activities in vitro, compounds 2, 3, 5, and 8 showed promising DPPH· scavenging activity with IC50 values ranging from 14.7 to 29.3 µM. Compounds 2, 3, 5, 7, and 8 exhibited promising potent activity in scavenging ABTS· with IC50 values in the range of 18–29.2 µM, which was stronger than that of the positive control ascorbic acid (IC50 = 33.6 ± 0.8 µM). |
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| Keywords: | mangrove endophytic fungus, Epicoccum nigrum, furobenzotropolone, DPPH· scavenging activity, ABTS· scavenging activity |
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