Colorectal distention in the horse: visceral sensitivity, rectal compliance and effect of i.v. xylazine or intrarectal lidocaine |
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Authors: | Sanchez L C Merritt A M |
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Institution: | Island Whirl Equine Colic Research Laboratory, College of Veterinary Medicine, University of Florida, Box 100136, Gainesville, Florida 32610-0136, USA. |
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Abstract: | REASONS FOR PERFORMING STUDY: Most current models of visceral sensitivity testing in the horse have required visceral cannulation. Colorectal distention (CRD) is a widely used, noninvasive method for testing in other species and could be adapted for use in horses. OBJECTIVES: To develop a protocol of controlled CRD in the conscious horse and to evaluate the effect of i.v. xylazine or intrarectal lidocaine on CRD threshold and rectal compliance. METHODS: Eight horses were used for baseline studies (3 trials each) and 6 horses to evaluate treatments (4 trials, 2 per treatment). A 45 cm diameter polyvinyl balloon attached to plastic tubing was used for rectal distention following a stepwise barostat-controlled inflation pattern. RESULTS: The procedure was well tolerated by all horses. Mean baseline threshold pressure was 14.17 mmHg. Xylazine i.v. resulted in significantly (P < 0.05) higher mean threshold pressures compared to baseline or rectal lidocaine. Rectal compliance increased following lidocaine treatment relative to baseline or xylazine. CONCLUSIONS: CRD offers a noninvasive method for visceral sensitivity testing in the horse. Xylazine raises CRD threshold, while lidocaine increases rectal compliance. POTENTIAL RELEVANCE: The increased rectal compliance following intrarectal lidocaine administration may explain the benefit of its use to facilitate rectal examination. |
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