Respiratory function and pulmonary lesions in pigs infected with porcine reproductive and respiratory syndrome virus |
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| Authors: | Judith Wagner Annette Kneucker Elisabeth Liebler-Tenorio Vicky Fachinger Melanie Glaser Stefan Pesch Michael P Murtaugh Petra Reinhold |
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| Institution: | a Institute of Molecular Pathogenesis in the ‘Friedrich-Loeffler-Institut’ (Federal Research Institute for Animal Health), Naumburger Str. 96a, 07743 Jena, Germany;b Boehringer Ingelheim Vetmedica GmbH, Corporate R&D, Binger Str. 173, 55216 Ingelheim, Germany;c Bioscreen EVDMC GmbH, Mendelstr. 11, 48149 Münster, Germany;d Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN 55108, USA |
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| Abstract: | Pulmonary dysfunction was evaluated in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV, isolate VR-2332) and compared to clinical and pathological findings. Infected pigs developed fever, reduced appetite, respiratory distress and dullness at 9 days post-inoculation (dpi). Non-invasive pulmonary function tests using impulse oscillometry and rebreathing of test gases (He, CO) revealed peripheral airway obstruction, reduced lung compliance and reduced lung CO-transfer factor. PRRSV-induced pulmonary dysfunction was most marked at 9–18 dpi and was accompanied by a significantly increased respiratory rate and decreased tidal volume. Expiration was affected more than inspiration. On histopathological examination, multifocal areas of interstitial pneumonia (more severe and extensive at 10 dpi than 21 dpi) were identified as a possible structural basis for reduced lung compliance and gas exchange disturbances. |
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| Keywords: | Porcine reproductive and respiratory syndrome virus Pulmonary function testing Pathology Pigs |
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