Lysozyme from rainbow trout, Salmo gairdneri Richardson, as an antibacterial agent against fish pathogens |
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Authors: | B GRINDE |
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Institution: | Department of Animal Husbandry and Genetics, Norwegian College of Veterinary Medicine and Department of Biotechnical Disease Control, National Veterinary Institute, Oslo, Norway |
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Abstract: | Abstract. The antibacterial effect of two lysozyme variants purified from rainbow trout, Salmo gairdneri Richardson, kidney was investigated as part of a project directed towards increasing the disease resistance of fish by the transgenic technique. Seven bacterial strains from five Gram-negative species, of which one was considered non-pathogenic, were examined. One of the rainbow trout lysozymes was surprisingly potent, having substantial antibacterial activity on all strains tested. Hen egg-white lysozyme was bactericidal only against the one species considered non-pathogenic. The data suggest that lysozyme does play a role in the disease defence of rainbow trout and that the gene for the most active lysozyme may be suitable for testing the transgenic strategy. |
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