Regulatory Effect and Mechanism of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α on Fatty Liver of Dairy Cows北大核心CSCD

The incidence of nutritional metabolic diseases in animal population is gradually increasing, with the development of animal husbandry to improve the quality of livestock breeding and livestock products. Fatty liver is a kind of nutritional metabolic disease with a high incidence in perinatal high-yielding dairy cows. During the perinatal period, dairy cows are usually in a negative energy balance, leading to excessive mobilization of body fat, resulting in accumulation of liver triglycerides and thus fatty liver. Dairy cows with fatty liver can reduce milk yield, prolong calving interval, and induce the occurrence of other diseases, which have a huge impact on the production performance of dairy cows and the development of animal husbandry. Peroxisome proliferator-activated receptor γ coactivator-1α (PCC-1α) is an important nuclear transcription coactivator, which participates in the interaction of various nuclear receptors and transcription factors to regulate the expression of related target genes. PCC-1α is closely related to fatty liver, ketosis and mastitis in dairy cows, and may be a new therapeutic target for these diseases. In this review, we reviewed the various molecular pathways involved in the regulation of PGC-1α, and further elucidated the latest research progress on the regulatory role of PGC-1α in fatty liver of dairy cows by regulating lipid metabolism, mitochondrial dysfunction, oxidative stress, insulin resistance and inflammatory response. © 2023 Chinese Journal of Animal Science and Veterinary Medicine Co., Ltd. All rights reserved.