Genetic diversity of growth hormone receptor gene in cattle |
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| Authors: | Bang Zhong LIN Shinji SASAZAKI June Heon LEE Hideyuki MANNEN |
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| Institution: | Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Nada, Kobe, Japan, and;Division of Animal Science and Resources, College of Agriculture and Life Sciences, Chungnam National University, Daejeon, Korea |
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| Abstract: | Growth hormone receptor (GHR) belongs to a member of the cytokine receptor superfamily. Polymorphism of presence or absence of an approximately 1.2 kbp LINE-1 element is observed in bovine GHR gene. The present study was carried out for estimating the genetic diversity and the origin of the LINE-1 element in 10 European, Southeastern Asian and East Asian cattle breeds or populations. Genotyping of the LINE-1 revealed predominant LINE-1 presence in European breeds (0.917～0.991), absence in the Bos taurus indicus populations (0.000～0.017), and intermediate presence in Northeast Asian cattle (0.417～0.522). From genetic features of LINE families, LINE-1 of GHR could be attributed to the same origin in both European and Asian cattle, and Asian LINE-1 may not be derived from recent introgression. This result suggested that LINE-1 in bovine GHR gene could have arisen in an ancestral population of Bos taurus taurus . |
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| Keywords: | cattle genetic diversity growth hormone receptor LINE |
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