Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their 13C-NMR Spectroscopic Data Characteristics |
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| Authors: | Fahd M Abdelkarem Mohamed E Abouelela Mohamed R Kamel Alaa M Nafady Ahmed E Allam Iman A M Abdel-Rahman Ahmad Almatroudi Faris Alrumaihi Khaled S Allemailem Hamdy K Assaf |
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| Institution: | 1.Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt; (F.M.A.); (M.E.A.); (A.M.N.); (A.E.A.); (H.K.A.);2.Department of Pharmacognosy, Faculty of Pharmacy, South Valley University, Qena 83523, Egypt;3.Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia; (A.A.); (K.S.A.) |
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| Abstract: | Gorgostane steroids are isolated from marine organisms and consist of 30 carbon atoms with a characteristic cyclopropane moiety. From the pioneering results to the end of 2021, isolation, biosynthesis, and structural elucidation using 13C-NMR will be used. Overall, 75 compounds are categorized into five major groups: gorgost-5-ene, 5,6-epoxygorgostane, 5,6-dihydroxygorgostane, 9,11-secogorgostane, and 23-demethylgorgostane, in addition to miscellaneous gorgostane. The structural diversity, selectivity for marine organisms, and biological effects of gorgostane steroids have generated considerable interest in the field of drug discovery research. |
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| Keywords: | gorgostane marine organisms 13C-NMR steroids |
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