人参果皂苷对实验性心肌缺血的保护作用 |
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引用本文: | 徐华丽,于晓风,曲绍春,睢大员.人参果皂苷对实验性心肌缺血的保护作用[J].人参研究,2003,15(2):2-4. |
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作者姓名: | 徐华丽 于晓风 曲绍春 睢大员 |
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作者单位: | 吉林大学药学院药理教研室,长春,130021 |
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基金项目: | 国家重点科技攻关项目 ( 96- 90 1 - 0 5 - 1 5 5 ) |
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摘 要: | 通过异丙肾上腺素及垂体后叶素诱发急性心肌缺血模型,观察人参果皂苷(GFS)对实验性心肌缺血的保护作用。结果表明,GFS30、60mg/kg对皮下注射异丙肾上腺素缩短小鼠的常压缺氧状态下的存活时间均具有明显对抗作用,20、40mg/kg均可明显减轻静脉注射垂体后叶素诱发的大鼠急性心肌缺血心电图(ST段抬高及T波高耸)变化程序,表明GFS对实验性心肌缺血具有明显的保护作用。
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关 键 词: | 人参果皂苷 实验性心肌缺血 保护作用 垂体后叶素 异丙肾上腺素 |
protective Effect of GFS on Expermental Myocardial Ischemia |
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Authors: | Xu Huali Yu xiaofeng Qu Shaochun Sui dayuan |
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Abstract: | Protective effect of Ginseng fruin saponins(GFS)on experimental myocardial ischemia was observed with acute myocardial ischemia model induced by isoprenaline (Isop.)in mice and posterior-pituitary (Pit)in rats.The results showed that GSF(30.60mg/kg,ip)could prolong significantly survival time in normal pressure anoxia induced by Isop. and GSF(20,40mg/kg,ip)could decrease degrees of myocardial ischemia ECG induced by Pit.it is indicated that GSF has the significant protective effect on myocardial ischemia. |
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Keywords: | GFS Myocardial Ischemia Isop Pit ECG |
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