Mapping the antigenic and genetic evolution of influenza virus |
| |
Authors: | Smith Derek J Lapedes Alan S de Jong Jan C Bestebroer Theo M Rimmelzwaan Guus F Osterhaus Albert D M E Fouchier Ron A M |
| |
Institution: | Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. dsmith@zoo.cam.ac.uk |
| |
Abstract: | The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains and thus estimation of the effects of vaccination. Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|