Protective Role of Oleuropein against Acute Deltamethrin-Induced Neurotoxicity in Rat Brain |
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| Authors: | Ali Reza Khalatbary Elmira Ghaffari Behrooz Mohammadnegad |
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| Institution: | 1.Molecular and Cell Biology Research Center, Dept. of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; ;2.Dept. of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran |
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| Abstract: | Background:Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. The purpose of this study was to determine the anti-apoptotic effect of OE pretreatment in the neuronal cells of cerebral cortex. Methods:Rats were randomly divided into four groups each containing five rats: DM-treated group (12.5 mg/kg, a single dose), OE-treated group (20 mg/kg per day), DM + OE-treated group, and vehicle group. Sections of the brain were obtained 24 hours after DM injection and studied for histopathological and immunohistochemistry assessment. Results:The histopathological assessments showed lesser characteristics of neural degeneration in DM + OE group compared with DM group. Greater Bcl-2 and attenuated Bax expression could be detected in the DM + OE treated-mice compared with DM group. Conclusion:The results suggested that DM-induced neurotoxicity can be subsided by OE.Key Words: Deltamethrin, Oleuropein, Apoptosis |
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