| 狂犬病（HEP／BHK_（21））活疫苗免疫期试验 |
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| 引用本文： | 郭万柱,陈代荣.狂犬病（HEP／BHK_（21））活疫苗免疫期试验[J].四川农业大学学报,1994,12(2):293-297. |
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| 作者姓名： | 郭万柱 陈代荣 |
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| 作者单位： | 四川农业大学，四川省兽医防疫检疫总站，四川畜牧兽医学院，四川省峨眉山市畜牧局，四川省资阳市畜牧局 |
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| 摘 要： | 应用效价为１０（－４．５０）ＭＩＣＬＤ（５０）／０．０３ｍｌ的狂犬病ＨＥＰ／ＢＨＫ（２１）活毒疫苗免疫犬后，对免疫前和免疫后１、３、６、１２、３０个月血样进行了血清学评价和免疫原性分析。１５只犬免疫１月后，血清抗体全部阳转，６６％的犬在３０个月后抗体仍维持在一个较高水平。免疫１年后９０％以上的动物能够得到保护。统计表明，不同地区、不同性别、不同年龄的犬免疫反应无显著差异，但三月龄以下犬反应欠佳。
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| 关 键 词： | 狂犬病（47MA），HEP／BHK_（21）活疫苗，免疫期，免疫测定（47KD），抗体（47KD）。 |
DURATION-OF-IMMUNITY STUDY IN DOGS OF RABIES LIVE VACCINE (HEP/BHK_(21)) |
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| Guo Wanzhu et al.DURATION-OF-IMMUNITY STUDY IN DOGS OF RABIES LIVE VACCINE (HEP/BHK_(21))[J].Journal of Sichuan Agricultural University,1994,12(2):293-297. |
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| Authors: | Guo Wanzhu |
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| Abstract: | A rabies live vaccine(HEP/BHK21) was tested in dogs to determine,its duration of immnnity and immunogenicity. Dogs were vaccinated intramuscularly with a field dose of vaccine which was 10-4. 50mouse intercerebral median lethal doses per0. 03ml. Blood samples were collected for serologic evaluation and immunogenicity test before inoculation and at 1; 3,6, 12, 30 months after vaccination. 15 dogs produced high titer antibodies against rabies virus at 1 month after vaccination 66% of degs had high antibody titer at 30 months post-vaccination.A result of serumneutralization showed that 85% of dogs could be protected at 1 year after vaccination.The resuets of the present study indicated there was no distinst different antibody response in dogs of different area,sex and age, except pups. |
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| Keywords: | RABIES VIRUS HEP/BHK_(21) LIVE VACCINE IMMUNITY DURATION |
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