The need for central and peripheral tolerance in the B cell repertoire |
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Authors: | C C Goodnow S Adelstein A Basten |
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Institution: | Centenary Institute for Cancer Medicine and Cell Biology, University of Sydney, New South Wales, Australia. |
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Abstract: | The immune system normally avoids producing antibodies that react with autologous ("self") antigens by censoring self-reactive T and B cells. Unlike the T cell repertoire, antibody diversity is generated within the B cell repertoire in two phases; the first occurs by gene rearrangement in primary lymphoid organs, and the second phase involves antigen-driven hypermutation in peripheral lymphoid organs. The possibility that distinct cellular mechanisms may impose self tolerance at these two different phases of B cell diversification may explain recent findings in transgenic mouse models, in which self-reactive B cells appear to be silenced both by functional inactivation and by physical elimination. |
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