新奥霉素母药对5种非靶标生物的急性毒性

测定了新奥霉素 (xinaomycin)母药对5种非靶标生物——斑马鱼Brachydanio rerio、大型溞Daphnia magna Straus、羊角月芽藻Pseudokirchneriella subcapitata、意大利工蜂Apis mellifera L.和家蚕Bombyx mori的急性毒性。结果显示:新奥霉素母药对斑马鱼96 h-LC₅₀值大于100 mg/L；对大型溞48 h-EC₅₀值为1.48 mg/L；对羊角月芽藻72 h-EyC₅₀值为8.74 mg/L，72 h-ErC₅₀值为29.2 mg/L；对意大利工蜂急性经口96 h-LD₅₀值为31.3 μg/蜂，急性接触96 h-LD₅₀值为39.9 μg/蜂；对家蚕96 h-LC₅₀值大于2.00×103 mg/L。研究表明，新奥霉素母药对斑马鱼、羊角月芽藻、蜜蜂、家蚕均为低毒，对大型溞是中等毒性。

Acute toxicity study of xinaomycin TK to five non-target organisms

The acute toxicities of xinaomycin TK to Brachydanio rerio, Daphnia magna Straus, Pseudokirchneriella subcapitata, Apis mellifera L. and Bombyx mori were investigated. According to the results, the 96 h-LC₅₀ value of xinaomycin TK to B. rerio was higher than 100 mg/L. And the 48 h-EC₅₀ value of xianomycin TK to D. magna was 1.48 mg/L. The 72 h-EyC₅₀ and the 72 h-ErC₅₀ value of xianomycin TK to P. subcapitata were 8.74 mg/L and 29.2 mg/L, respectively. The 96 h-LD₅₀ value of xianomycin TK to A. mellifera were 31.3 μg/bee by acute oral method and 39.9 μg/bee by acute contact method. The 96 h-LC₅₀ value of xianomycin TK to B. mori was over 2.00×103 mg/L. The acute toxicity test showed that xianomycin TK is low risk to B. rerio, D. magna, P. subcapitata, A. mellifera and B. mori and it has medium toxicity to D. magna.