| GT1-7细胞及其在生殖相关研究中的应用 |
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| 引用本文： | 冯涛,吴晓敏,许晓玲,白佳桦,宋玉清,肖霖力,韩向敏,刘彦. GT1-7细胞及其在生殖相关研究中的应用[J]. 东北农业大学学报, 2016, 0(1): 102-108. DOI: 10.3969/j.issn.1005-9369.2016.01.015 |
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| 作者姓名： | 冯涛 吴晓敏 许晓玲 白佳桦 宋玉清 肖霖力 韩向敏 刘彦 |
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| 作者单位： | 1. 北京市农林科学院畜牧兽医研究所,北京,100097;2. 甘肃农业大学动物科学技术学院,兰州,730070 |
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| 基金项目： | 国家自然科学基金，北京市科技新星计划项目，奶牛产业技术体系北京市创新团队 |
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| 摘 要： | GT1-7细胞是GT1细胞株的亚株,通过转基因技术从小鼠下丘脑分离获得的Gn RH神经元细胞系,具有高度分化的神经内分泌细胞典型特征。下丘脑Gn RH合成和释放对生殖功能具有重要作用,而Gn RH神经元在脑内数量少且呈弥散分布,体内研究较困难。目前,GT1-7细胞是研究Gn RH神经元的理想离体细胞模型,在生殖相关研究中广泛使用。文章详细阐述GT1-7细胞获得过程、功能特性及其在生殖系统研究中应用,以及影响GT1-7细胞活性的信号通路,以期对动物生殖调控研究提供参考。
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| 关 键 词： | GT1-7细胞 促性腺激素释放激素 生殖调控 信号通路 |
GT1-7 cells and its application in reproduction-related researches |
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| Abstract: | GT1-7 cells were subset strains of GT1 cell lines, which were GnRH neuron cell line isloated from the hypothalamus of transgenic mice and had the typical characteristics of highly differentiated neuroendocrine cells. GnRH synthesis and release in hypothalamus played an important role in reproductive function. However, GnRH neurons were only thousands and discrete distribution in the brain, which leads more difficulties in studying in vivo. Currently, GT1-7 cell was widely using in reproduction-related research works as an ideal GnRH cell model in vitro. In this review, the source, characteristics, applications as well as signaling pathways influencing ability of GT1-7 cells were summarized to provide references for GnRH related researches. |
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| Keywords: | GT1-7 cells gonadotropin-releasing hormone reproductive regulation signaling pathway |
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