Pharmacokinetics and bioavailability of a long-acting formulation of cephalexin after intramuscular administration to cats |
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Authors: | G.A. Albarellos L. Montoya M.F. Landoni |
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Affiliation: | a Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Chorroarín 280 (1427), Buenos Aires, Argentina b Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, 60 y 118, Buenos Aires, Argentina |
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Abstract: | The pharmacokinetic profile and bioavailability of a long-acting formulation of cephalexin after intramuscular administration to cats was investigated. Single intravenous (cephalexin lysine salt) and intramuscular (20% cephalexin monohydrate suspension) were administered to five cats at a dose rate of 10 mg/kg. Serum disposition curves were analyzed by noncompartmental approaches. After intravenous administration, volume of distribution (Vz), total body clearance (Clt), elimination constant (λz), elimination half-life (t½λ) and mean residence time (MRT) were: 0.33 ± 0.03 L/kg; 0.14 ± 0.02 L/h kg, 0.42 ± 0.05 h−1, 1.68 ± 0.20 h and 2.11 ± 0.25 h, respectively. Peak serum concentration (Cmax), time to peak serum concentration (Tmax) and bioavailability after intramuscular administration were 15.67 ± 1.95 μg/mL, 2.00 ± 0.61 h and 83.33 ± 8.74%, respectively. |
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Keywords: | Cephalexin Pharmacokinetics Cats Intramuscular Long-acting formulation Bioavailability |
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