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Metabolism of fenitrothion by organophosphorus-resistant and -susceptible house flies, Musca domestica L
Authors:Masashi Ugaki  Toshio Shono  Jun-ichi Fukami
Institution:1. Laboratory of Applied Entomology, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan;2. Department of Medical Zoology, School of Medicine, University of Occupational and Environmental Health, Japan, Yahata-Nishi-ku, Kitakyushu 807, Japan;3. Insect Physiology and Toxicology Laboratory, Institute of Physical and Chemical Research, Wako, Saitama 351, Japan
Abstract:The metabolism of fenitrothion was investigated in highly resistant (Akita-f) and susceptible (SRS) strains of the house fly, Musca domestica L. The Akita-f strain was 3500 times more resistant to fenitrothion than the SRS strain. Fenitrothion, topically applied to the flies, was metabolized in vivo far faster in the Akita-f strain than in the SRS strain. In vitro studies revealed that fenitrothion was metabolized by a cytochrome P-450-dependent monooxygenase system and glutathione S-transferases. The former oxidase system metabolized fenitrothion in vitro into fenitrooxon and 3-methyl-4-nitrophenol as major metabolites, and into 3-hydroxymethyl-fenitrothion and 3-hydroxymethyl-fenitrooxon as minor metabolites. Glutathione S-transferases metabolized fenitrothion into desmethylfenitrothion. The cytochrome P-450-dependent monooxygenase system and glutathione S-transferases of the resistant Akita-f strain had 1.4 to 2.2 times and 9.7 times, respectively, as great activities as those of the susceptible SRS strain. These results suggest the importance of glutathione S-transferases in fenitrothion resistance in the Akita-f strain.
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