首页 | 本学科首页   官方微博 | 高级检索  
     


Heat‐inactivated Mycobacterium bovis protects zebrafish against mycobacteriosis
Authors:Vladimir López  María Angeles Risalde  Marinela Contreras  Lourdes Mateos‐Hernández  Joaquin Vicente  Christian Gortázar  José de la Fuente
Affiliation:1. Instituto de Investigación en Recursos Cinegéticos IREC‐CSIC‐UCLM‐JCCM, SaBio, Ciudad Real, Spain;2. Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma
Abstract:Control of mycobacterial infection constitutes a priority for human and animal health worldwide. However, effective vaccines are needed for the control of human and animal tuberculosis (TB). Adult zebrafish have become a useful model for studying the pathophysiology of mycobacterial infection and for the development of novel interventions for TB control and prevention. Recently, parenteral and oral immunization with the heat‐inactivated Mycobacterium bovis vaccine (M. bovis IV) protected wild boar against TB. The objectives of this study were to provide additional support for the role of M. bovis IV in TB control using the zebrafish model and to conduct the first trial with this vaccine for the control of fish mycobacteriosis. The results showed that M. bovis IV protected zebrafish against mycobacteriosis caused by low and high infection doses of Mycobacterium marinum and provided evidence suggesting that the protective mechanism elicited by M. bovis IV in zebrafish as in other species is based on the activation of the innate immune response through the C3 pathway, with a role for the regulatory protein Akr2 in this process. These results encourage the use of M. bovis IV for TB control in different species.
Keywords:complement component C3  fish innate immunity  fish mycobacteriosis  tuberculosis  vaccine  zebrafish
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号