Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor |
| |
| Authors: | K Yamasaki T Taga Y Hirata H Yawata Y Kawanishi B Seed T Taniguchi T Hirano T Kishimoto |
| |
| Institution: | Division of Immunology, Osaka University, Japan. |
| |
| Abstract: | Interleukin-6 (IL-6/BSF-2/IFN beta 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. A complementary DNA encoding the human IL-6 receptor (IL-6-R) has now been isolated. The IL-6-R consists of 468 amino acids, including a signal peptide of approximately 19 amino acids and a domain of approximately 90 amino acids that is similar to a domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of approximately 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors. |
| |
| Keywords: | |
|
|
