| 一种低值海参蛋白酶解物降血压活性的研究 |
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| 引用本文： | 赵元晖,李八方,曾名湧,董士远,刘尊英. 一种低值海参蛋白酶解物降血压活性的研究[J]. 渔业现代化, 2009, 36(1) |
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| 作者姓名： | 赵元晖 李八方 曾名湧 董士远 刘尊英 |
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| 作者单位： | 中国海洋大学食品科学与工程学院,青岛,266003 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 通过水解低值海参--海地瓜(Acaudina molpadioides)的体壁蛋白,制备出具有显著抗高血压效果的水解产物.海地瓜的体壁蛋白先后被菠萝蛋白酶和alcalase蛋白酶水解,利用超滤技术,把水解产物分级成>2 kDa和<2 kDa两种组分.<2 kDa的组分具有很强的血管紧张素转换酶(ACE)抑制活性,其IC50值为0.615 mg/mL.肾血管性高压大鼠灌胃给药(<2 kDa的组分)1个月后,与模型组相比,其收缩压和舒张压均有明显下降,呈剂量依赖性,其中120 μg/g剂量的降压效果与卡托普利10 μg/g相当.
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| 关 键 词： | 海地瓜 ACE抑制活性 复合酶解 肾血管性高压大鼠 抗压效果 |
Study on antihypertensive activity of a lower-value sea cucumber protein hydrolysate |
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| ZHAO Yuan-hui,LI Ba-fang,ZENG Ming-yong,DONG Shi-yuan,LIU Zun-ying. Study on antihypertensive activity of a lower-value sea cucumber protein hydrolysate[J]. Fishery Modernization, 2009, 36(1) |
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| Authors: | ZHAO Yuan-hui LI Ba-fang ZENG Ming-yong DONG Shi-yuan LIU Zun-ying |
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| Affiliation: | College of Food Science and Engineering;Ocean University of China;Qingdao 266003;China |
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| Abstract: | The purpose of the paper was to prepare hydrolysate of Acaudina Molpadioides body wall protein with high antihypertensive activity.Acaudina Molpadioides body wall protein was hydrolyzed sequentially with bromelain and alcalase.The hydrolysate was fractionated into two ranges of molecular weight(>2 kDa;<2 kDa) using an ultrafiltration membrane bioreactor system.The fraction(<2 kDa) brought about a high ACE inhibitory activity,with IC50 value of 0.615 mg/mL.The fraction(<2 kDa) was used as drinks administered... |
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| Keywords: | Acaudina molpadioides ACE inhibitory activity combined-enzymic hydrolysis renal hypertensive rat antihypertensive effect |
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