In quest of genomic treasure |
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| Authors: | Kimiko INOUE Atsuo OGURA |
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| Affiliation: | 1)RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan;2) Graduate School of Life and Environmental Science, University of Tsukuba, Ibaraki 305-8572, Japan;3)The Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan |
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| Abstract: | It should be emphasized that “129” is not simply a number but is also the designation of a mouse strain thathas made a great contribution to modern biological science and technology. Embryonic stem cells derived from129 mice were essential components of gene-targeting strategies in early research. More recently, 129 micehave provided superior donor genomes for cloning by nuclear transfer. Some factor or factors conferringgenomic plasticity must exist in the 129 genome, but these remain unidentified. |
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| Keywords: | Embryonic stem cell Genomic reprogramming Mouse Nuclear transfer |
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