Developmental capacity and implantation potential of the embryos with multinucleated
blastomeres |
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| Authors: | Akiyoshi EGASHIRA Nobuhiko YAMAUCHI Keiko TANAKA Chihiro MINE Hitomi OTSUBO Masao MURAKAMI Md. Rashedul ISLAM Misako OHTSUKA Naomi YOSHIOKA Takashi KURAMOTO |
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| Affiliation: | 1)Kuramoto Women’s Clinic, Fukuoka 812-0013, Japan;2)Department of Animal and Marine Bioresource Sciences, Graduate School Kyushu University, Fukuoka 812-8581, Japan;3)Department of Genetics and Animal Breeding, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh |
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| Abstract: | The presence of multinucleated blastomeres (MNBs) in embryos is associated with poor developmentalcompetence in assisted reproductive technologies. This phenomenon is observed not only in humans but also inother animal species. The purpose of the present study was to investigate the characteristics of embryos withMNBs (MNB embryos) that could be utilized in embryo transfer. The developmental rate of MNB embryos to theblastocyst stage (50.8%) was significantly lower than that of normal embryos (73.3%) (P < 0.05). Theclinical pregnancy rates of fresh embryo transfer (ET) using day 2 or day 3 embryos were significantly lowerin MNB embryos (5.1%) compared with normal embryos (24.0%) (P < 0.05). In the case of frozen-thawed ETusing a single vitrified/warmed blastocyst, however, the clinical pregnancy rate of MNB embryos was close tothat of normal embryos (59.1% vs. 52.8%). Thus, the findings of the present study suggestthat the frozen-thawed ET of MNB embryos might improve the potential for implantation followed by successfulpregnancy. |
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| Keywords: | Blastocyst transfer Human embryos Implantation Multinucleated blastomeres |
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