| 猪黑素皮质素受体4基因的单倍型检测与分析 |
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| 引用本文： | 张冬杰. 猪黑素皮质素受体4基因的单倍型检测与分析[J]. 黑龙江农业科学, 2011, 0(12): 14-15 |
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| 作者姓名： | 张冬杰 |
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| 作者单位： | 黑龙江省农业科学院畜牧研究所,黑龙江哈尔滨,150086 |
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| 摘 要： | 黑素皮质素受体4（melanocortin 4receptor,MC4R）是G蛋白耦联受体超家族的一个成员,在人和许多动物的体重、能量稳态和采食量的调控中发挥重要作用。现采用直接克隆测序的方法对23头长白猪、25头大白猪、19头民猪和7头野猪的MC4R基因进行了测序与分型。共检测到SNP位点72个,其中发生频率在2次以上的SNP位点有6个,有3个为错义突变,引起了多肽链氨基酸的替代;6个SNP位点共组成了14种单倍型,其中H1、H3、H5、H6、H7、H9、H11和H14为首次发现的单倍型。
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| 关 键 词： | 猪 黑素皮质素受体4基因 测序 单倍型 |
Porcine MC4R Gene Haplotypes Detection and Analysis |
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| ZHANG Dong-jie. Porcine MC4R Gene Haplotypes Detection and Analysis[J]. Heilongjiang Agricultural Science, 2011, 0(12): 14-15 |
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| Authors: | ZHANG Dong-jie |
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| Affiliation: | ZHANG Dong-jie(Animal Husbandry Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang 150086) |
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| Abstract: | Melanocortin-4 receptor（MC4R）is a member of the superfamily of G protein coupled receptors,which affects body weight,energy homeostasis and food intake in human and many animals.The coding region of MC4R gene in 23 landrace,25 large white pig,19 Min pig and 7 wild boar were investigated using clone sequence method.The results showed that 72 SNPs were found,the frequency in which happened more than twice were 6,3 were missense mutation,caused the substitution of amino acids polypeptide chain.6 SNPs composed 14 haplotype,H1,H3,H5,H6,H7,H9,H11 and H14 were first found. |
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| Keywords: | pig MC4R gene sequence haplotype |
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