| 白术提取液急性毒性试验 |
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| 引用本文： | 王东升,李锦宇,罗超应,郑继方,张世栋,胡振英. 白术提取液急性毒性试验[J]. 西北农业学报, 2011, 20(5): 40-43 |
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| 作者姓名： | 王东升 李锦宇 罗超应 郑继方 张世栋 胡振英 |
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| 作者单位： | 中国农业科学院兰州畜牧与兽药研究所,兰州,730050;中国农业科学院临床兽医学研究中心,兰州,730050 |
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| 基金项目： | 中央级公益性科研院所基本科研业务费专项资金项目 |
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| 摘 要： | 测定白术提取液对小鼠腹腔注射和肌内注射的急性毒性,评价其安全性,为临床安全用药提供依据.采用最大给药量法,将60只小鼠随机分为3组,每组20只,分为白术提取液100g/kg腹腔注射组、20 g/kg肌内注射组和生理盐水100mL/kg腹腔注射组,注射给药后连续观察7 d,测定其1日最大给药量,确定白术提取液的急性毒性.结果表明,小鼠腹腔注射和肌内注射的1日最大给药量依次为100和20 g/kg,分别相当于临床犬日用量的400和80倍.说明白术提取液较为安全,可在临床研究试用.
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| 关 键 词： | 白术 急性毒性 小鼠 最大给药量 |
The Acute Toxicity of Extract from Rhizoma Atractylodis macrocephalae |
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| WANG Dongsheng,LI Jinyu,LUO Chaoying,ZHENG Jifang,ZHANG Shidong and HU Zhenying. The Acute Toxicity of Extract from Rhizoma Atractylodis macrocephalae[J]. Acta Agriculturae Boreali-occidentalis Sinica, 2011, 20(5): 40-43 |
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| Authors: | WANG Dongsheng LI Jinyu LUO Chaoying ZHENG Jifang ZHANG Shidong HU Zhenying |
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| Affiliation: | WANG Dongsheng1,2,LI Jinyu1,LUO Chaoying1,ZHENG Jifang1,ZHANG Shidong1,2 and HU Zhenying1,2(1.Lanzhou Institute of Animal Science and Veterinary Pharmaceutics,CAAS,Lanzhou 730050,China,2.Research Center of Clinical Veterinary Medicine,China) |
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| Abstract: | To evaluate safety of extract from Rhizoma Atractylodis macrocephalae,the acute toxicity in mice was determined by intraperitoneal injection and intramuscular injection.According to maximum dosage regimen design,60 mice were randomly divided into 3 groups with 10 females and 10 males in each group.Two different dose groups of extract from Rhizoma Atractylodis macrocephalae were 100 g/kg body mass by intraperitoneal injection and 20 g/kg body mass by intramuscular injection.The other group is the control inj... |
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| Keywords: | Rhizoma Atractylodis macrocephalae Acute toxicity Mouse Maximum dosage |
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