牛羊胎儿过大综合征的研究进展

牛、羊的胚胎在囊胚阶段之前,暴露 于各种特殊环境,妊娠后能导致过大胎儿的 产出,并有可能伴随出现胎儿多个器官功能 的缺陷,此称为胎儿过大综合征。最近几年, 全世界范围内在实施胚胎移植、克隆等这些 需要对胚胎进行多种体外操作的项目中,已 有相当数量的过大或畸形胎牛、胎羊出生。 对于某项具体的胚胎工程项目而言,胎儿过 大综合征发生率从0%～100%,这就极大地 限制了胚胎体外生产、核移植等繁育新技术 在畜牧业上的大规模应用。文章从该综合征 的临床表现、产生的原因、发生时间及导致其 发生的分子机制等几个方面,简要综述了近 几年国外有关胎儿过大综合征的研究与报 道。

Progress of Study on Large Offspring Syndrome

Bovine and ovine embryos which were exposed to a variety of unusual environments before the blastocyst stage had resulted in the development of unusual large offspring,as well as a number of organ defects.This was always called Large offspring syndrome.In recent years,lots of abnormal large calves and lambs had been born in the world.This was the project of embryo transplant or clone which needed various manipulation of the embryo in vitro.The incidence of large offspring syndrone subsequent to one project Daried from none to almost 100%.This had greatly limited the large-scale use of new breeding methods in stockbreeding, such as IVP, nuclear transplant.This article was intend to review the foreign reseachs and reports on the cause,clinical phenotype,timing of the perturbation and the underlying machanism of the Large offspring syndrome in recent years.