N-1,3,4- 口 恶 二唑基-N'-对溴苯氧乙酰基硫脲的合成及其抑菌活性

从对溴苯氧乙酸出发,先合成中间体酰基异硫氰酸酯,该中间体与2-氨基-5-芳基-1,3,4- 口 恶 二唑反应合成了10个新的苯氧乙酰基硫脲类化合物,其结构经元素分析、红外光谱、核磁共振氢谱和质谱确认。初步生物活性测试结果表明,在50 mg/L浓度下,所有目标化合物对水稻纹枯病菌Rhizatonia solani和黄瓜灰霉病菌Botrytis cinereapers的抑制率均达85％以上,部分化合物对黄瓜灰霉病菌的抑制率达100%。

Synthesis and Fungicidal Activity of N-(1,3,4-Oxadiazol-2-yl)-N'- 4-bromo-phenoxyacetylthioureas

A series of N-(1,3,4-oxadiazol-2-yl)-N'-4-bromo-phenoxyacetylthioureas were synthesized used substituted 2-amino-5-aryl-1,3,4-oxadiazoles reacted with substituted acetylthiocyanoester which obtained from p-bromophenoxyacetic acid. Their structures were confirmed by IR,¹H NMR and elemental analysis. The preliminary bioassay showed that the compounds synthesized had fungicidal avtivities.The inhibition rate of all the compounds to Rhizatonia solani and Botrytis cinereapers could reach 85% at the concentration of 50 mg/L.The inhibition rate of some compounds to B.cinereapers were 100% at the same concentration.