Evaluation of antirotavirus activity of flavonoids |
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| Authors: | Luciane Anita Savi, Thiago Caon, Ana Paula de Oliveira, Andrea Michel Sobottka, Wolfgang Werner, Fl vio Henrique Reginatto, Eloir Paulo Schenkel, C lia Regina Monte Barardi,Cl udia Maria Oliveira Sim es |
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| Affiliation: | a Laboratório de Virologia Aplicada, Departamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC, 88.040-970, Brazil;b Laboratório de Virologia Aplicada, Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC, 88.040-970, Brazil;c Curso de Farmácia, Universidade de Passo Fundo, Passo Fundo, RS, 99.001-970, Brazil;d Department of Pharmaceutical Chemistry, University of Münster, Hittorfstrasse 58-62, D-48149, Münster, Germany |
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| Abstract: | Flavonoids are dietary components and the most ubiquitous phenolic compounds found in nature, showing a range of pharmacological activities including antiviral action. This study describes the antiviral screening of 60 different flavones and flavonols against human rotavirus (Wa-1 strain) as well as their cytotoxicity in MA104 cells. Cytotoxicity was investigated by cell morphology assessment and antirotavirus activity by cytopathic effect inhibition. Results were expressed as CC50 and IC50, respectively, in order to calculate the selectivity index (SI = CC50/IC50) of each compound. Structure–activity relationships (SAR) were proposed based on antirotavirus activity. |
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| Keywords: | Antiviral screening Flavonoids Rotavirus SAR |
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