| Study on Changes of Plasma Endothelin—1 in Sheep with Experimental Colonic Obstruction |
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| 引用本文： | WANG Jing fei 1,SU Lei 2,JIANG Yong ping 3,DING Zheng hua 2,YUE Hai ning 2,XIANG Guang hua 2,WANG Hong bin 1 1(College of Veterinary Medicine,Northeast Agricultural University,Harbin,150030) 2(Department of Veterinary Medicine,Gansu Agric. Study on Changes of Plasma Endothelin—1 in Sheep with Experimental Colonic Obstruction[J]. 东北农业大学学报(英文版), 2001, 8(2): 100-104 |
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| 作者姓名： | WANG Jing fei 1 SU Lei 2 JIANG Yong ping 3 DING Zheng hua 2 YUE Hai ning 2 XIANG Guang hua 2 WANG Hong bin 1 1(College of Veterinary Medicine Northeast Agricultural University Harbin 150030) 2(Department of Veterinary Medicine Gansu Agric |
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| 作者单位： | WANG Jing fei 1，SU Lei 2，JIANG Yong ping 3，DING Zheng hua 2，YUE Hai ning 2，XIANG Guang hua 2，WANG Hong bin 1 1(College of Veterinary Medicine，Northeast Agricultural University，Harbin，150030 |
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| 摘 要： | 1 Introduction Endothelin is a peptide hormone with potentvasoconstrictor action that was firstisolat-ed from cultured porcine aortic endothelial cells( Yangisawa M,et al. 1 988) .The vasocon-strictive properties,modulatory actions on the rennin- angiotensin- aldosterone system,andantinatriuretic effects of endothelin have been well characterized in vitro and in vivo ( Simon-son MS,etal .1 989) .Although such peptide action suggestan important regulatory action,apotential role of endoth…
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| 关 键 词： | 绵羊 实验性结肠梗阻 血浆内皮素1变化 |
Study on Changes of Plasma Endothelin-1 in Sheep with Experimental Colonic Obstruction |
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| WANG Jing-fei,SU Lei,JIANG Yong-ping,DING Zheng-hua,YUE Hai-ning,XIANG Guang-hua,WANG Hong-bin. Study on Changes of Plasma Endothelin-1 in Sheep with Experimental Colonic Obstruction[J]. Journal of Northeast Agricultural University, 2001, 8(2): 100-104 |
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| Authors: | WANG Jing-fei SU Lei JIANG Yong-ping DING Zheng-hua YUE Hai-ning XIANG Guang-hua WANG Hong-bin |
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| Abstract: | The present study was designed to determine the relationship between changes of plasma endothelin-1concentrations and development of colonic obstruction in sleep. Colons were bound in three sheep with sterilized plastic tubes to make pathological model of colonic obstruction. Samples were collected before and after modeling operation on both controls and models. Endothelin-1 concentrations were measured by radioimmunoassay. Plasma ET-11evels decreased continually after the modeling operation in the models,it dropped from a basal value of 60. 93±-18.66 to 34. 11±8.22 and 33. 54±11.12 pg/mL( P <0.05) on the 3rd and 5th day,respectively,which were also lower than controls 64. 16±12.93 pg/mL( P <0. 05). It suggests that colonic obstruction may induce a decrease in plasma endothelin-1 concentrations in sleep. |
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| Keywords: | endothelin 1 colonic obstruction sheep |
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