Interaction of pyrethroids with mammalian spinal neurons |
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Institution: | 1. CiToxLAB North America, 445 Armand Frappier, Laval, QC H7V 4B3, Canada;2. Department of Toxicology, Purdue Pharma L.P., Cranbury, NJ 08512, USA;3. Unit of Pharmacology, Faculty of Veterinary Medicine, Université de Montréal, P.O. Box 5000, St.-Hyacinthe, QC J2S 7C6, Canada |
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Abstract: | The effects of intravenous administration of non-cyano (cis-permethrin) and cyano-substituted (deltamethrin) pyrethroids were studied on spontaneous and evoked ventral root activity in rat spinal cord and on spontaneous firing of ventral horn interneurons in the cat. Both pyrethroids had dramatic facilitatory effects on spontaneous firing rates of ventral roots and spinal interneurons and increased the amplitude of mono- and polysynaptically mediated ventral root responses to dorsal root stimulation. Spontaneous and evoked afferent sensory activity was slightly enhanced by cis-permethrin, but not by deltamethrin. In the cat diazepam (0.5 mg/kg, iv) was equally effective in antagonizing the facilitation of interneuronal firing resulting from either deltamethrin or cis-permethrin. These effects of pyrethroids on spinal neurons may underly the production of tremor and choreoathetosis-salivation toxicity symptoms in mammals. |
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