Toxicokinetics of dicamba (3,6-dichloro-2-methoxy-benzoic acid) and its 3,5-dichloro isomer following intravenous administration to rats |
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| Institution: | 1. Laboratoire de pharmacocinétique, faculté de pharmacie, université Paris Descartes, 75004 Paris, France;2. Plateforme biologie du médicament, UF pharmacocinétique et pharmacochimie, hôpital Cochin, AP–HP, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France;1. Faculty of Chemical Technology, Poznan University of Technology, 60-965 Poznan, Poland;2. Molecular Biology Techniques Laboratory, Faculty of Biology, Adam Mickiewicz University in Poznań, 61-614 Poznan, Poland;3. Department of Molecular Ecology, Institute of Aquaculture and Environmental Safety, Hungarian University of Agriculture and Life Sciences, Páter K. u. 1., 2100 Gödöllő, Hungary;4. Institute for Environmental Studies, Faculty of Science, Charles University, Benátská 2, Prague 2, Czech Republic;5. Department of Environmental Biotechnology, Helmholtz Centre for Environmental Research – UFZ, Permoserstraße 15, 04318 Leipzig, Germany |
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| Abstract: | The distribution and elimination of dicamba (3,6-dichloro-2-methoxy benzoic acid) and another isomer present in dicamba formulation (3,5-dichloro-2-methoxy benzoic acid) were studied in rats following single intravenous injections. Concentrations of dicamba and the isomer were measured at various times in whole blood by EC-GLC after extraction and derivatization with diazomethane. The isomer had different toxicokinetic parameters compared to dicamba. The elimination of dicamba from the blood was rapid with a biological half-life of 0.64 hr (following 100 mg/kg iv dose) while the elimination of the isomer from the blood was much slower with a biological half-life of 16.5 hr (following 20 mg/kg iv dose). However, upon combined dosing of the two compounds the elimination rate constant of dicamba significantly decreased. The isomer had a greater degree of binding to blood serum proteins than dicamba. |
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