丙泊酚注射液对靶动物犬的安全性评价

为研究丙泊酚注射液对靶动物犬的安全性,选取健康成年贵宾犬32只,随机分为4组,每组8只,各组试验犬分别按0、1倍推荐剂量(5.5 mg·kg^-1·bw^-1)、3倍推荐剂量(16.5 mg·kg^-1·bw^-1)、5倍推荐剂量(27.5 mg·kg^-1·bw^-1)单剂量静脉注射丙泊酚注射液,并对各组试验犬进行临床观察及各项生理指标检查。结果显示,各组试验犬血液学及血液生化指标变化均在正常范围内,苏醒后各组试验犬生理指标与空白对照组差异不显著,5倍推荐剂量组与空白对照组试验犬各脏器均未观察到异常病理变化。除3倍和5倍推荐剂量组部分试验犬出现呼吸抑制外,各剂量组试验犬均未出现死亡等其他不良反应。试验表明,丙泊酚注射液按推荐剂量给药对靶动物犬是安全的。

Target Animal Safety Evaluation to Propofol Injection in Dogs

To evaluate the safety of propofol injection in dogs,32 healthy adult Poodle dogs were divided into 4 groups randomly,each group was given propofol injection at a single dose of 0,recommended dosage(5.5 mg·kg^-1·bw^-1),3 times of recommended dosage(16.5 mg·kg^-1·bw^-1)and 5 times of recommended dosage(27.5 mg·kg^-1·bw^-1)respectively.During the experiment,clinical signs were observed,general pathology and histopathology change were measured,and blood samples were collected for hematology and biochemistry.The results showed that the changes of hematology and biochemical parameters in each group were within the normal range.There was no significant difference between various indicators compared with the blank group after recovery.No pathology changes were observed in the group of blank and 5 times of recommended dosage.Except some dogs in the group of 3 and 5 times of recommended dosage had occurred respiratory depression,no other adverse reactions and deaths were observed in each group.In conclusion,the recommended dose of propofol injection was safe to dog.