Rhabdomyosarcoma in the Japanese medaka, Oryzia latipes (Temminck & Schlegel) and guppy, Poecilia reticulata Peters |
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Authors: | W. E. HAWKINS J. W. FOURNIE R. M. OVERSTREET W. W. WALKER |
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Affiliation: | Gulf Coast Research Laboratory, Ocean Springs, Mississippi, USA |
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Abstract: | Abstract. Three cases of skeletal muscle neoplasms occurring in two small fish species used in carcinogen tests are reported. The cases illustrated a wide range of histologic patterns, and consisted of a well-differentiated juvenile type, a well-differentiated pleomorphic type and a poorly differentiated pleomorphic type. A rhabdomyosarcoma with juvenile type features developed in the Japanese medaka, Oryzias latipes , exposed to 0·5 ml/1 of the solvent dimethylformamide. A pleomorphic type rhabdomyosarcoma occurred in one medaka and in one guppy, Poecilia reticulata , exposed to the carcinogen methylazoxymethanol acetate. These cases indicate the potential for skeletal muscle cells in medaka and guppy to become neoplastic but, because the tumours occurred at a low frequency, there may not necessarily be a chemical aetiology. |
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