Clinical significance of plasma mannose concentrations in healthy and diabetic dogs |
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Authors: | A Mori T Sato P Lee M Furuuchi H Tazaki K Katayama H Mizutani T Sako T Arai |
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Institution: | (1) Department of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan;(2) Department of Veterinary Nursing, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan |
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Abstract: | Circulating levels of monosaccharides can act as a reflection of systemic glucose/ energy metabolism. Characteristic changes
observed in these levels can be seen in patients with diabetes and other metabolic disorders. There have been a few reports
describing the significance of mannose metabolism as an energy source under physiological and pathological conditions. However,
the relationship between circulating levels of mannose and the pathophysiology of diabetes mellitus are unknown in dogs. This
study examined circulating levels of mannose between healthy control and diabetic dogs and evaluated the clinical significance
of mannose levels in dogs. Diabetic dogs demonstrated a higher circulating level of mannose in comparison to normal healthy
control dogs. Plasma mannose was positively correlated with plasma glucose and fructosamine, respectively. Interestingly,
plasma mannose levels were affected by plasma insulin levels. In the context of feeding and glucose tolerance tests, plasma
mannose levels responded to changes in circulating insulin levels. Circulating plasma mannose levels decreased after feeding
in both control and diabetic animals in spite of observed insulin level differences. However, when glucose tolerance tests
were given, a positive correlation between mannose levels and insulin levels was observed. Therefore, plasma mannose levels
obtained via glucose tolerance testing may be used as a new diagnostic method for evaluating insulin resistance or deficiency
in diabetic dogs. |
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Keywords: | Diabetes Dog Insulin Mannose |
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