Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis |
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| Authors: | Chia-Ching Liaw Yu-Chi Lin Yun-Sheng Lin Chung-Hsiung Chen Tsong-Long Hwang Ya-Ching Shen |
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| Affiliation: | 1.School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan; E-Mails: (C.-C.L.); (Y.-C.L.); (Y.-S.L.); (C.-H.C.);2.Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan;3.Department of Life Sciences, National Cheng Kung University, No. 1 University Road, Tainan 701, Taiwan;4.Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan; E-Mail: |
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| Abstract: | Four new 8-hydroxybriarane diterpenoids, frajunolides P–S (1–4), together with umbraculolide A, juncenolide C, junceellonoid A and juncin R, were isolated from the acetone extract of the gorgonian Junceella fragilis, collected from the southeast coast of Taiwan. Compound 1 contains an unusual pivaloyloxy group at C-2, while 3 is a rare compound having a chlorine atom on the olefinic carbon (C-6). The structures of the isolated compounds were established by extensive spectroscopic analysis, including 1D- and 2D-NMR, as well as HRMS data. Compound 1 was further confirmed by X-ray crystallographic analysis. In the anti-inflammatory test, compounds 1 and 2 exhibited moderate inhibition on superoxide anion generation and elastase release by human neutrophils in response to formylmethionylleucyl-phenylalanine/dihydrocytochalasin B (fMLP/CB). |
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| Keywords: | Junceella fragilis briarane-type diterpenoids frajunolides anti-inflammatory |
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