Cloning of a serotonin transporter affected by antidepressants |
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| Authors: | B J Hoffman E Mezey M J Brownstein |
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| Affiliation: | Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892. |
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| Abstract: | A complementary DNA clone for a serotonin (5HT) transporter has been isolated from rat basophilic leukemia cells. The complementary DNA sequence predicts a 653-amino acid protein with 12 to 13 putative transmembrane domains. The 5HT transporter has significant homology to the gamma-aminobutyric acid, dopamine, and norepinephrine transporters. Uptake by CV-1 cells expressing the transporter complementary DNA resembles 5HT uptake by platelets and brain synaptosomes; it is sensitive to antidepressants, amphetamine derivatives, and cocaine. |
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