| 顶复门原虫γ-氨基丁酸代谢旁路研究进展 |
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| 引用本文： | 胡俊菁,戚南山,吴彩艳,李娟,吕敏娜,林栩慧,于林增,张健騑,廖申权,孙铭飞.顶复门原虫γ-氨基丁酸代谢旁路研究进展[J].中国动物传染病学报,2020(2):98-103. |
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| 作者姓名： | 胡俊菁 戚南山 吴彩艳 李娟 吕敏娜 林栩慧 于林增 张健騑 廖申权 孙铭飞 |
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| 作者单位： | 广东省农业科学院动物卫生研究所广东省畜禽疫病防治研究重点实验室农业农村部兽用药物与诊断技术广东科学观测实验站 |
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| 基金项目： | “十三五”重点研发专项(2017YFD0501205);国家自然科学基金(31602044,31872460);广东省科技计划项目(2016A040403079,2016B020202005);广东省农业科学院学科团队建设项目(201623TD)。 |
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| 摘 要： | 顶复门原虫包括一大类单细胞寄生性原虫,是人和动物的重要病原,会对人类健康以及畜牧业生产造成严重危害。γ-氨基丁酸是一种四碳非蛋白质氨基酸,广泛存在于生物体内。顶复门原虫的γ-氨基丁酸代谢旁路主要参与能量代谢,为虫体生长提供短期的能量储备,在虫体适应不同寄生环境过程中起着关键性作用。寄生原虫的γ-氨基丁酸代谢明显区别于哺乳动物宿主,仅限于中枢神经系统中的代谢,可在虫体入侵宿主细胞及有性生殖阶段发挥重要的作用。本文对顶复门原虫γ-氨基丁酸代谢途径及其生物学作用进行综述。
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| 关 键 词： | 顶复门原虫 Γ-氨基丁酸 生物学功能 |
PROGRESS INγ-AMINOBUTYRIC ACID SHUNT IN APICOMPLEXAN PARASITES |
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| HU Jun-jing,QI Nan-shan,WU Cai-yan,LI Juan,Lyu Min-na,LIN Xu-hui,YU Lin-zeng,ZHANG Jian-fei,LIAO Shen-quan,SUN Ming-fei.PROGRESS INγ-AMINOBUTYRIC ACID SHUNT IN APICOMPLEXAN PARASITES[J].Chinese Journal of Animal Infectious Diseases,2020(2):98-103. |
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| Authors: | HU Jun-jing QI Nan-shan WU Cai-yan LI Juan Lyu Min-na LIN Xu-hui YU Lin-zeng ZHANG Jian-fei LIAO Shen-quan SUN Ming-fei |
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| Institution: | (Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province,Ministry of Agriculture and Rural Affairs,Key Laboratory of Livestock Disease Prevention of Guangdong Province,Institute of Animal Health,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China) |
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| Abstract: | The phylum Apicomplexa contains a large group of unicellular parasites that are the main causative pathogens for some of the important infectious diseases in human and livestock.Theγ-aminobutyric acid(GABA)is a non-protein four carbon amino acid,which is present in most prokaryotes and eukaryotes.The presence of GABA shunt in apicomplexan parasites is involved in energy metabolism and essential in response to different stages of parasites with different nutrition.The GABA metabolism of a protozoon is different from that in host due to the fact that GABA receptors exist only in the mammalian central nervous system.This system is protected by the bloodbrain barrier.Therefore,the GABA inhibitors are less toxic to a mammalian host than to parasites that lack such barrier.Theγ-aminobutyric acid can play an important role in the invasion of host cells and sexual reproduction.This review will focus on the research progress on metabolism and biological function of GABA in apicomplexan parasites. |
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| Keywords: | Apicomplexan γ-aminobutyric acid biological function |
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