Renal hemodynamic and diuretic effects of low-dosage dopamine in anesthetized cats |
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| Authors: | James S. Wohl DVM Diplomate ACVIM ACVECC Dean D. Schwartz PhD W. Shannon Flournoy DVM MS Terrence P. Clark DVM PhD Diplomate ACVCP James C. Wright DVM PhD Diplomate ACVPM |
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| Affiliation: | Department of Small Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, AL,;Department of Anatomy, Physiology &Pharmacology, College of Veterinary Medicine, Auburn University, AL, and;Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL,;Eli Lilly and Company, Indianopolis, IN. |
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| Abstract: | Objective: To evaluate the effects of low‐dosage (3 μg/kg/min) dopamine on urine output, renal blood flow, creatinine clearance, sodium excretion, heart rate, and mean arterial pressure (MAP) in healthy anesthetized cats. Design: Controlled experimental study. Setting: University experimental laboratory. Animals: Twelve random‐bred 2–4‐year‐old cats. Interventions: Anesthesia, laparotomy for renal artery blood flow measurement, and arterial and venous catheterization. Measurements: Heart rate (HR), MAP, renal blood flow, urine output, sodium excretion, fractional sodium excretion, and creatinine clearance. Main results: No significant difference in urine output, sodium excretion, HR, or creatinine clearance occurred in cats receiving low‐dosage dopamine. A transient decrease in the mean arterial blood pressure occurred in cats receiving dopamine. Conclusions: Low‐dosage dopamine cannot be expected to induce diuresis in healthy cats. Low‐dosage dopamine may cause vasodilation in non‐renal vascular beds. |
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| Keywords: | diuresis dopaminergic feline renal protection urine output |
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