| 一氧化氮／一氧化氮合酶与血吸虫感染 |
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| 引用本文： | 蒋韦斌,林矫矫.一氧化氮／一氧化氮合酶与血吸虫感染[J].中国兽医寄生虫病,2008,16(6):41-45. |
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| 作者姓名： | 蒋韦斌 林矫矫 |
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| 作者单位： | 1. 上海师范大学生命与环境科学学院,上海,200234;中国农业科学院上海兽医研究所/国家防治动物血吸虫病专业实验室/农业部动物寄生早学重点,开放实验室,上海200241
2. 中国农业科学院上海兽医研究所/国家防治动物血吸虫病专业实验室/农业部动物寄生早学重点,开放实验室,上海200241 |
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| 摘 要： | 一氧化氮合酶（NOS）家族中诱生型一氧化氮合酶（iNOS）在细胞因子或脂多糖刺激下，催化合成的一氧化氮（N0）对多种寄生虫具有杀伤作用。因此，认识一氧化氮在抗血吸虫感染中的作用，有着重要的理论意义和潜在的临床应用价值。本文就一氧化氮的生物学特性、生物合成、作用机制以及近年来一氧化氮／一氧化氮合酶在血吸虫学研究中的应用作一综述。
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| 关 键 词： | 一氧化氮 一氧化氮合酶 血吸虫感染 |
NITRIC OXIDE/NITRIC OXIDE SYNTHASE AND SCHISTOSOMAL INFECTION |
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| JIANG Wei-bin,LIN Jiao-jiao.NITRIC OXIDE/NITRIC OXIDE SYNTHASE AND SCHISTOSOMAL INFECTION[J].Chinese Journal of Veterinary Parasitology,2008,16(6):41-45. |
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| Authors: | JIANG Wei-bin LIN Jiao-jiao |
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| Institution: | JIANG Wei-bin, LIN Jiao-jiao (1. Shanghai Normal University, Shanghai 200232. China ;2. Key Laboratory of Animal Parositology , Ministry of Agriculture /National Laboratory of Animal Schitosomiasis Control /Shanghai veterinary Research Institute, CAAS , Shanghai 200232, China) |
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| Abstract: | iNOS , one of the family of NOS isoforms, catalyzed and synthesized NO when stimulated by lipopolysaccharide or induced by cytokine. It was found that parasites could be killed by NO. Thus, it is of important theoretical and potential value of clinical application to understand that NO catalyzed and synthesized by iNOS against parasite infection. This article reviewed the information of NO including biological characters, biosynthesis, mechanism of action and the recent applications in the field of schistosome. |
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| Keywords: | Nitric oxide nitric oxide synthase schistosomal infection |
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