Fluorophotometric evaluation of experimental blood-aqueous barrier disruption in dogs |
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| Authors: | D A Ward D C Ferguson R L Kaswan K Green R W Bellhorn |
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| Affiliation: | Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602. |
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| Abstract: | A protocol for performing slit-lamp fluorophotometry of the anterior chamber in dogs was established. The technique was then used to develop a model of blood-aqueous barrier disruption that can be used for comparative testing of ophthalmic anti-inflammatory drugs. It was determined that barrier disruption induced by a slow, controlled paracentesis of a small volume of aqueous humor may provide the most reliable model for drug testing. Additionally, fluorophotometry proved to be a sensitive and accurate means of detecting breakdown of the blood-aqueous barrier. |
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