Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase |
| |
Authors: | Sofia Cavaco Matthew K Williamson Joana Rosa Vânia Roberto Odete Cordeiro Paul A Price M Leonor Cancela Vincent Laizé Dina C Simes |
| |
Institution: | 1. Centre of Marine Sciences (CCMAR/CIMAR-LA), University of Algarve, Campus de Gambelas, 8005-139, Faro, Portugal 2. Faculty of Sciences and Technology, University of Algarve, 8005-139, Faro, Portugal 3. Division of Biology, University of California San Diego, La Jolla, CA, 92093-0368, USA 4. Department of Biomedical Sciences and Medicine, University of Algarve, 8005-139, Faro, Portugal 5. GenoGla Diagnostics, CCMAR, University of Algarve, 8005-139, Faro, Portugal
|
| |
Abstract: | The occurrence of a second osteocalcin (OC2) has been reported in teleost fish, where it coexists with OC1 in some species. While it has been proposed that OC2 gene originated from OC1 through the fish whole-genome duplication event, little information is available on its molecular function and physiological role. The present study brings biological data supporting the presence of OC2 in the mineral phase of teleost fish bone and its association with the mineral phase together with OC1. The occurrence of OC2 forms with different levels of phosphorylation or γ-carboxylation, and with amino acid substitutions was observed. Comparative analysis of mature peptide sequences revealed the high conservation existing between OC1 and OC2, in particular within the core γ-carboxyglutamic acid domain, and suggests that both protein forms may have the same function, i.e., binding of calcium ions or hydroxyapatite crystals. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|