氧含量急剧变化对冷血脊椎动物氧化压力的影响

氧气对大多生物体至关重要,但是氧气能转变为活性氧从而对机体产生毒性。多种冷血脊椎动物可耐受自然条件下产生的氧化压力,如某些鱼、蛙、龟和蛇等。综述了缺氧/低氧耐受性动物在环境、代谢产生供氧不足时的应对方式。对比这些动物的应对方式后发现了某些抗氧化能力提高的规律。机体一般采用关键抗氧化酶的酶活增强、谷胱甘肽含量增多来抵御氧化压力。

Cold-blooded Vertebrates Response to Drastic Changes in Oxygen Availability on Oxidative Stress

Oxygen plays an important role in most organisms.But it can transform into reactive oxygen species(ROS),leading to toxic effects.Several cold-blooded vertebrates were found to tolerate the natural oxidative stress,for example,some fishes,turtles,frogs and snakes.The responses of anoxia/hypoxia-tolerant animals when faced to environmental and metabolic stresses leading to oxygen limitation were reviewed.Certain patterns emerge when comparing the responses from these animals.The increase activity of key antioxidant enzymes and/or glutathione levels is in preparation for a putative oxidative stress.