高亲和性镍钴转运系统的研究进展

镍作为生物体必需的微量元素,存在于一些与能量和氮代谢相关的金属酶中。钴主要参与维生素B12的合成,再进一步被含维生素B12的酶利用。由于环境中只存在微量的镍和钴,生物体为满足其对镍和钴的需求,形成了高亲和性的镍钴吸收系统。目前对微生物的研究中发现,高亲和性镍和钴的吸收主要依赖于ABC(ATP-binding cassette)转运家族和其他一些次级转运蛋白(secondary transport-ers)。文中对这两方面的研究进展进行了综述,并对其末来研究发展进行了展望。

Research Progresses on High-affinity Nickel/Cobalt Transport Systems

As an essential trace eleent,Nickel is the component of metalloenzymes involved in energy and nitrogen metabolism.Cobalt is mainly found in the synthesis of vitamin B12,and then further used by coenzyme B12.Synthesis of nickel and cobalt enzymes is dependent on high-affinity uptake of the metal ions from natural environments where they are available only in trace amounts.High-affinity nickel and cobalt uptake in microorganisms is mainly mediated by ATP-binding cassette(ABC) systems and by secondary transporters.The research progress of these two aspects was reviewed,and the future development was forecasted.