| 猪瘟病毒持续性感染的分子机制 |
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| 引用本文： | 李军,曾芸.猪瘟病毒持续性感染的分子机制[J].动物医学进展,2006,27(12):23-26. |
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| 作者姓名： | 李军 曾芸 |
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| 作者单位： | 广西兽医研究所,广西南宁,530001;广西大学动物科技学院,广西南宁,530005;广西大学动物科技学院,广西南宁,530005 |
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| 摘 要： | 猪瘟病毒的持续性感染是典型急性猪瘟感染以外的一种感染形式,在这类感染中,感染猪并不表现明显的临床症状,但是却长期携带病毒成为重要的传染源。研究表明,猪瘟病毒是通过对细胞溶解性感染的调节,引起树突状细胞无应答,诱导淋巴细胞凋亡,抑制I型干扰素产生和囊膜糖蛋白E2变异等多个方面来逃脱机体的免疫应答,从而建立持续性感染。
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| 关 键 词： | 猪瘟病毒 持续性感染 分子机制 |
| 文章编号： | 1007-5038（2006）12-0023-04 |
| 收稿时间： | 2006-09-29 |
| 修稿时间： | 2006年9月29日 |
Molecular Mechanism of Persistent Infection of Classical swine fever virus |
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| LI Jun,ZENG Yun.Molecular Mechanism of Persistent Infection of Classical swine fever virus[J].Progress In Veterinary Medicine,2006,27(12):23-26. |
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| Authors: | LI Jun ZENG Yun |
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| Institution: | 1. Guangxi Veterinary Institute, Nanning, Guangxi, 530001, China; 2. College of Animal Science and Technology, Guangxi University, Nanning , Guangxi, 530005, China |
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| Abstract: | Persistent infection of Classical swine fever virus (CSFV) is another infectious form except acute infection. In this form, infected pigs do not show the visible clinical symptom, but CSFV stay in pigs for a long time and become a significant infection source. Current research indicated that CSFV could evade the immune response and establish persistent infection through regulating cytolysis, inducing dendritic cell unresponse, inducing lymphocyte apoptosis, inhibiting the production of interferon type I and the variation of envelop glycoprotein E2. |
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| Keywords: | Classical swine fever virus persistent infection molecular mechanism |
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