Study on Pharmacokinetics of Compound Traditional Chinese Medicine Preparation for Locoweed Detoxication |
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Authors: | HAO Bao-cheng QUAN Xiao-di YE Yong-li GAO Xu-dong HUANG Xin WANG Xue-hong LIU Jian-zhi WANG Bao-hai LIANG Jian-ping |
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Institution: | 1. Key Laboratory of New Animal Drug Project, Gansu Province Key Laboratory of Veterinary Pharmaceutics Discovery, Ministry of Agricultural, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China;2. College of Life Science and Engineering, Northwest University for Nationalities, Lanzhou 730030, China;3. Tibet Academy of Agriculture and Animal Husbandry, Lasa 850000, China |
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Abstract: | The test was conducted to study the pharmacokinetics of compound traditional Chinese medicine preparation for locoweed detoxication in rats.After oral drug preparations,the absorption circumstances of active ingredients in vivo were detected by ultraviolet spectrophotometry and then the relative pharmacokinetic parameters were calculated based on identifying the effective components.The results showed that a suitable ultraviolet spectrum analytical method was established for 8 compounds at first.It had shown that the effective components were absorbed into the blood quickly after oral administration,and the maximum plasma concentration of each composition was got after about 1 h,indicating that the efficacy developed rapidly.The metabolic rates of Codonopsis pilosula saponin,polysaccharide and ferulic acid were fast,while the action time of the metabolites of glycyrrhizic acid,saikosaponin,astraloside and prim-O-glucosylc-imifugin were longer.The results suggested that pharmacolinetic process of this medicine preparation in rats basically conformed with two compartment model (expect the hesperidin).The determination method was simple,and had high accuracy and stability,as well as suitable for the pharmacokinetic study. |
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Keywords: | compound traditional Chinese medicine preparation pharmacokinetics UV spectrophotometry locoweed |
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